Original papers

  1. New!! Hattammaru M, Tahara Y, Kikuchi T, Okajima K, Konishi K, Nakajima S, Sato K, Otsuka K, Sakura H, Shibata S, Nakaoka T. The effect of night shift work on the expression of clock genes in beard hair follicle cells. Sleep Med. 2019, pii: S1389-9457(18)30593-30598. ⇒Pubmed
  2. New!! Morinaga K, Sasaki H, Park S, Hokugo A, Okawa H, Tahara Y, Colwell CS, Nishimura I.Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism. Biomaterials.2019, 192:62-74. ⇒Pubmed
  3. Kuljis D, Kudo T, Tahara Y, Ghiani CA, Colwell CS, Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington's disease. J Neurosci Res. 2018, in press. ⇒Pubmed
  4. Whittaker DS, Loh DH, Wang HB, Tahara Y, Kuljis D, Cutler T, Ghiani CA, Shibata S, Block GD, Colwell CS, Circadian-based treatment strategy effective in the BACHD mouse model of Huntington’s disease, Journal of Biological rhythms, 2018, 33:535-554. ⇒Pubmed
  5. Takahashi M, Tahara Y, Tsubosaka M, Fukazawa M, Ozaki M, Iwakami T, Nakaoka T, and Shibata S, Chronotype and social jetlag influence human circadian clock gene expression, Scientific Reports, 2018, 8:10152. ⇒Pubmed
  6. Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S. Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function. Scientific Reports, 2018, 8:9072. ⇒Pubmed
  7. Tahara Y, Yamazaki M, Sukigara H, Motohashi H, Sasaki H, Miyakawa H, Haraguchi A, Ikeda Y, Fukuda S, Shibata S. Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainme5t in Mouse Peripheral Tissue. Scientific Reports, 2018, 8:1395. ⇒Pubmed
  8. Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y, Shibata S. Night eating model shows time-specific depression-like behavior in the forced swimming test. Scientific Reports, 2018, 8:1081. ⇒Pubmed
  9. Hassan N, McCarville K, Morinaga K, Mengatto CM, Langfelder P, Hokugo A, Tahara Y, Colwell CS, Nishimura I, Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells. PLoS ONE, 2017, 12:e0183359.⇒PubMed
  10.  Kamagata M, Ikeda Y, Sasaki H, Hattori Y, Yasuda S, Iwami S, Tsubosaka M, Ishikawa R, Todoh A, Tamura K, Tahara Y, Shibata S, Potent Synchronization of Peripheral Circadian Clocks by Glucocorticoid Injections in PER2::LUC-Clock/Clock mice. Chronobiol Int., 2017, 13:1-16. ⇒PubMed
  11. Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, Kikuchi Y, Haraguchi A, Shibata S, Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice, Nutrition Research, 2017, 43:16-24.⇒Nutrition Research
  12. Shinozaki A, Misawa K, Ikeda Y, Haraguchi A, Kamagata M, Tahara Y, Shibata S, Potent Effects of Flavonoid Nobiletin on Ampliturde, Period, and Phase of the Circadian Clock Rhythm in PER2::LUC Mouse Embryonic Fibroblasts. PLoS One. 2017, 12:e0170904.⇒PubMed
  13. Tahara Y, Takatsu Y, Shiraishi T, Kikuchi Y, Yamazaki M, Motohashi H, Muto A, Sasaki H, Haraguchi A, Kuriki D, Nakamura TJ, Shibata S, Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation, npj Aging and Mechanisms and Disease, 2017, 3:16030.⇒npj Aging HP⇒Nature Asia
  14. Takahashi M, Haraguchi A, Tahara Y, Aoki N, Fukuzawa M, Tanisawa K, Ito T, Nakaoka T, Higuchi M, Shibata S, Positive association between physical activity and PER3 expression in older adults. Scientific Reports, 2017, 7:39771.⇒PubMed
  15. Sasaki H, Hattori Y, Ikeda Y, Kamagata M, Iwami S, Yasuda S, Tahara Y, Shibata S, Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice. Scientific Reports, 2016, 6:27607.⇒PubMed
  16. Tahara Y, Yokota A, Shiraishi T, Yamada S, Haraguchi A, Shinozaki A, Shibata S, In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress, Journal of Circadian Rhythms, 2016, 14:1-7. ⇒JCR HP
  17. Li H, Ohta H, Tahara Y, Nakamura S, Taguchi K, Nakagawa M, Oishi Y, Goto Y, Wada K, Saga M, Inagaki M, Otagiri M, Yokota H, Shibata S, Sakai H, Okamura K, Yaegashi N, Artificial oxygen carriers rescue placental  hypoxia and improve fetal development in the rat pre-eclampsiamodel.  Scientific Reports, 2015, 5:15271.⇒PubMedプレスリリース
  18. Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S., Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. Scientific Reports, 2015, 5:14424.⇒PubMed
  19. Hamaguchi Y*, Tahara Y*, Kuroda H, Haraguchi A, Shibata S. Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions. Scientific Reports, 2015, 5:14207. (*equal contribution)⇒PubMed
  20. Hamaguchi Y, Tahara Y, Hitosugi M, Shibata S. Impairment of Circadian Rhythms in Peripheral Clocks by Constant Light Is Partially Recovered by Scheduled Feeding or Exercise. J Biological Rhythms, 2015, 30:533-542. ⇒PubMed
  21. Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, Kamagata M, Yang ZH, Hirasawa A, Tahara Y, Shibata S. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. PLoS ONE, 2015, 10:e0132472. ⇒PubMed
  22. Tahara Y, Shiraishi T, Kikuchi Y, Haraguchi A, Kuriki D, Sasaki H, Motohashi H, Sakai T & Shibata S. Entrainment of the mouse circadian clock by sub-acute physical and psychological stress. Scientific Reports, 2015, 5:11417. ⇒Journal注目の論文
  23. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Phase-delay in the light-dark cycle impairs clock gene expression and levels of serotonin, norepinephrine, and their metabolites in the mouse hippocampus and amygdala. Sleep Medicine, 2015, 16:1352-1359. ⇒PubMed
  24. Moriya S, Tahara Y, Sasaki H, Ishigooka J, Shibata S. Housing under abnormal light-dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice. Neuroscience Research, 2015, 99:16-21. ⇒PubMed
  25. Ikeda Y, Sasaki H, Ohtsu T, Shiraishi T, Tahara Y, Shibata S, Feeding and adrenal entrainment stimuli are both necessary for normal circadian oscillation of peripheral clocks in mice housed under different photoperiods. Chronobiology International, 2015, 32:195-210. ⇒PubMed
  26. Narishige S, Kuwahara M, Shinozaki A, Okada S, Ikeda Y, Kamagata M, Tahara Y,Shibata S. Effects of caffeine on circadian phase, amplitude, and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice. British Journal of Pharmacology, 2014, 171:5858-5869. ⇒PubMed
  27. Aoki N, Yoshida D, Ishikawa R, Ando M, Nakamura K, Tahara Y, and Shibata S, A single daily meal at the beginning of the active or inactive period inhibits food deprivation-induced fatty liver in mice. Nutr Res, 2014, 34:613-622. ⇒PubMed
  28. Moriya S, Tahara Y, Sasaki H, Hamaguchi Y, Kuriki D, Ishikawa R, Ishigooka J, Shibata S, Effect of Quetiapine on Per1, Per2, and Bmal1 Clock Gene Expression in the Mouse Amygdala and Hippocampus. J Pharmacol Sci, 2014, 125:329-332. ⇒PubMed
  29. Haraguchi A, Aoki N, Ohtsu T, Ikeda Y, Tahara Y, and Shibata S, Controlling access time to a high fat diet during the inactive period protects against obesity in mice, Chronobiology International, 2014, 31:935-944. ⇒PubMed
  30. Ohnishi N*, Tahara Y*, Kuriki D, Haraguchi A, and Shibata S, Warm water bath stimulates phase-shifts of the peripheral circadian clocks in PER2::LUCIFERASE mouse, PLoS ONE, 2014, 9:e100272, (*These authors equally contributed this work.⇒PubMed
  31. Nakamura Y*, Ishimaru K*, Tahara Y*, Shibata S, Nakao A, Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice, J Immunological Research, 2014, 2014:ID474217. (*These authors equally contributed this work.) ⇒PubMed
  32. Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A, Circadian Regulation of Allergic Reaction by the Mast Cell Clock. J Allergy Clin Immunol, 2014, 133:568-575. ⇒PubMed
  33. Kudo T, Loh DH, Tahara Y, Truong D, Hernández-Echeagaray E, Colwell CS, Circadian dysfunction in response to the in vivo treatment with the mitochondrial toxin 3-nitropropionic acid. ASN Neuro, 2014, 6:e00133. ⇒PubMed
  34. KudoT, Tahara Y, Gamble KL, McMahon DG, Block GD, Colwell CS, Vasoactive intestinal peptide produces long lasting changes in neural activity in the suprachiasmatic nucleus. J of Neurophysiol, 2013, 110: 1097-1106. ⇒PubMed
  35. Kuroda H*, Tahara Y*, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, Shibata S, Meal frequency patterns determine the phase of mouse peripheral circadian clocks. Sci Rep, 2012, 2: 711. (*These authors equally contributed this work.) ⇒PubMed
  36. Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S, Biological clock dysfunction exacerbates contact hypersensitivity in mice. Br J Dermatol, 2012, 168; 39-46. ⇒PubMed
  37. Fuse Y, Hirao A, Kuroda H, Otsuka M, Tahara Y, Shibata S, Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism. J Circadian Rhythms, 2012, 10: 4. ⇒PubMed
  38. Tahara Y, Kuroda H, Saito K, Nakajima Y, Kubo Y, Ohnishi N, Seo Y, Otsuka M, Fuse Y, Ohura Y, Komatsu T, Moriya Y, Okada S, Furutani N, Hirao A, Horikawa K, Kudo T, Shibata S, In Vivo Monitoring of Peripheral Circadian Clocks in the Mouse. Curr Biol, 2012, 22: 1029-1034. ⇒PubMed
  39. Kubo Y, Tahara Y, Hirao A, Shibata S, 2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2::Luciferase knockin mice: lack of dependence on anesthetic activity. J Pharmacol Exp Ther, 2012, 340: 698-705. ⇒PubMed
  40. Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I, Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J Med Chem, 2011, 54: 6295-6304. ⇒PubMed
  41. Tahara Y, Otsuka M, Fuse Y,Hirao A, and Shibata S, Restricted feeding elicits insulin-dependent regulation of Per2 and Rev-erba gene expression as an early step in entrainment of the liver clock, J Biol Rhythms, 2011, 26: 230-240. ⇒PubMed
  42. Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A, The circadian clock gene Period2 regulates a time of day-dependent variation in cutanenous anaphylactic reaction. J Allergy Clin Immunol, 2011, 127: 1038-1045. ⇒PubMed
  43. Hirao A, Nagahama H, Tsuboi T, Hirao M, Tahara Y, Shibata S. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::luc knock-in mice under two meals per day feeding. Am J Physiol Gastrointest Liver Physiol, 2010, 299: G1045-1053. ⇒PubMed
  44. Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S, Dorsomedial hypothalamus is not necessary for the feeding-induced entrainment of liver circadian rhythm in Per2::luc knock-in mouse. J Biol Rhythms, 2010, 25: 9-18. ⇒PubMed
  45. Hirao A, Tahara Y, Kimura I, Shibata S, A balanced diet is necessary for proper entrainment signals of the mouse liver clock. PLoS One, 2009, 4, e6909. ⇒PubMed



  1. New!! 田原 優、『体を整えるすごい時間割』、大和書房、2019. ⇒Amazon  ⇒大和書房
  2. 田原 優、「体内時計と時間栄養」、『特集『時間』を軸に考えた糖尿病治療の新展開』、月刊糖尿病、医学出版、2018年7月 ⇒月刊糖尿病
  3. 田原 優、「時間栄養学的な観点からの疾病予防」、『特集・実臨床に向けた時間医薬研究の新動向』、医療ジャーナル、2018年6月、123-128 ⇒医療ジャーナル
  4. 田原 優、柴田 重信、『Q&Aですらすらわかる 体内時計健康法』、杏林書院、2017. ⇒杏林書院
  5. 田原 優、柴田 重信、「体内時計、時間栄養学」、『食品機能成分の吸収・代謝・作用機序』、シーエムシー出版、2018、30-37. ⇒シーエムシー出版
  6. Tahara Y and Shibata S, Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition. Free Radic Biol Med. 2017 ⇒Pub Med
  7. Tahara Y and Shibata S, Abnormal tuning of the hepatic circadian metabolic rhythms in lung cancer. Hepatology, 2016, 65:1061-1064. ⇒Pub Med
  8. 柴田 重信、田原 優、「日内変動・生物リズム」、マウス表現型解析スタンダード、実験医学、羊土社、2016、289-294.
  9. Tahara Y, Aoyama S, Shibata S, The mammalian circadian clock and its entrainment by stress and exercise. J Physiological Science, 2017, 76:1-10.  ⇒Pub Med
  10. Tahara Y & Shibata S, Circadian rhythms of liver physiology and disease: experimental and clinical evidence, Nature Reviews Gastroenterology and Hepatology, 2016, 13:217-226. ⇒Nature Reviews
  11. Yu Tahara, Hiroyuki Sasaki, Shigenobu Shibata, Chrono-nutrition and Chrono-exercise in Mice, アショフホンマ財団 『Circadian Clocks』, 2015, p53-59.
  12. 田原 優「連載〜概日時計研究を健康に活かす〜」、全7回、体育の科学、杏林書院、2015、11月号〜 ⇒杏林書院
  13. 柴田 重信、田原 優「時間薬理・栄養・運動学の研究最前線」、実験医学11月号、2015、p3008-3011. ⇒羊土社
  14. Shibata S, Tahara Y, Circadian Rhythm & Exercise, J Phys Fitness Sports Med., Review, 2014, 3:65-72. J Phys Fitness Sports Med
  15. Tahara Y, Shibata S, Chrono-biology, chrono-pharmacology, and chrono-nutrition, J pharm Sci., Review, 2014, 124:320-335. ⇒PubMed
  16. Tahara Y, Shibata S, Chronobiology and Nutrition. Neuroscience, Review, 2013, 253: 78-88. ⇒PubMed
  17. Tahara Y, Shibata S, Nutrition and diet as potent regulators of the liver clock. Circadian rhythms: Health and Disease, Wiley, in press ⇒Wiley
  18. Tahara Y, Shibata S, Circadian rhythm and food/nutrition. Mechanisms of Circadian Systems in Animals and Their Clinical Relevance, Springer, 2014, 237-260. ⇒Springer
  19. 田原 優、柴田 重信、「時間栄養と心の健康〜食品との関わりも含めて」FOOD STYLE 21、食品化学新聞社、2013年8月、p42-44. ⇒食品化学新聞社
  20. 田原 優、柴田 重信、「時間栄養学」『食品機能性成分の吸収・代謝機構』、シーエムシー出版、2013年5月、p28-36. ⇒シーエムシー出版
  21. 田原 優、柴田 重信、「日内リズムを作る身体のしくみ」『子どもと発育発達』、日本発育発達学会、杏林書院、2011, 8: p259-263. ⇒杏林書院
  22. 田原 優、 柴田 重信、「子供の体内時計と遺伝」、乳幼児医学・心理学研究』、日本乳幼児医学・心理学会、2010, 19, 89-96.
  23. Shibata S, Tahara Y, Hirao A, The adjustment and manipulation of biological rhythms by light, nutrition, and abused drugs, Advanced Drug Delivery Reviews, 2010, 62, 918-927. ⇒PubMed
  24. 田原 優、柴田 重信、「行動薬理研究における実験技術~概日リズム評価法~」、『実践行動薬理学』、日本薬理学会、金芳堂、第Ⅰ編、4章、p27-p34.     ⇒日本薬理学会
  25. Shibata S, Hirao A, Tahara Y, Restricted feeding-induced entrainment of activity rhythm and peripheral clock rhythm, Sleep & Biological Rhythms, 2010, 8, 18-27. ⇒Wiley